I had a little play around, and I still decided to go with mostly what I was already using in Beta 3.
That said, I decided to move the target bar, status effects, and focus HP bar down by my hotbars so I can see them easily during a battle without having to "look up". Especially important for evading monsters charging attacks now.
Most of my slots look empty, but I can't drag items, macros, or gearsets onto them with this HUD simulator. But I did actually have most of those boxes used up in beta.